Cancer Gene Sequencing
For customers wishing to identify SNP biomarkers in tumor samples, Cogenics offers a cancer gene sequencing service. We conduct laser capture microdissection or macrodissection to isolate tumor cells, then extract, amplify and purify DNA from these cells. Cogenics achieves read lengths of up to 800 bases of phred 20.

As part of this service, Cogenics will design and synthesize custom primers or identify and use appropriate primers from its proprietary HAP® Database. The HAP® Database is a collection of SNPs and haplotypes (which we call HAP™ Markers) for > 8,000 genes.  The HAP® Database includes location and context sequence of each SNP discovered in Cogenics’ standard Index Repository (representing the major populations of the world in 93 well-characterized individuals), HAP™ Markers discovered in this Index Repository, and frequencies of SNPs and HAP™ Markers in each population group in the Index Repository. Cogenics’ DecoGen® Informatics System performs data analysis of HAP® Database information, with the ability to identify probable associations between SNPs and clinical outcomes. DecoGen® is also compatible with SNP data from public and client databases.

Benefits of Cogenics’ cancer gene sequencing service include:

• Access to proprietary HAP® Database content
• Custom primer design and synthesis
• Sequencing conducted in duplicate or triplicate
• High pass rates
• Highest quality sequencing data

Samples
Clients are required to submit tumor samples.

Results
All Final Reports include SNP scores and identification and haplotype marker identification tables.