Whole Genome Analysis
Our clients conducting genome wide association studies, chromosome copy number studies, linkage analyses, and population genetic studies generally interrogate from 50,000 - 1 million SNPs per sample. For these applications, Cogenics offers genotyping services based on the Affymetrix GeneChip® System, using a choice of 25-mer probe length microarrays:

• Genome-Wide SNP array 6.0: Enables highly powered whole-genome association studies, population genetics, and linkage disequilibrium analysis. It  features more than 1.8 million markers for genetic variation, including more than 906,600 single nucleotide polymorphisms (SNPs) and more than 946,000 probes for the detection of copy number variation
  
  
• Genome-Wide SNP array 5.0: Is a single microarray featuring all single nucleotide polymorphisms (SNPs) from the original two-chip Mapping 500K Array Set, as well as 420,000 additional probes that can measure other genetic differences, such as copy number variation.
  
  
• GeneChip® Human Mapping 500K Array Set: Enables highly powered whole-genome association studies, population genetics, and linkage disequilibrium analysis. It is comprised of two arrays, each capable of genotyping ~ 250,000 SNPs.
  
  
• GeneChip® Human Mapping 100K Set: Enables copy number and allele specific analysis. It is comprised of a set of two arrays.
  
  
• GeneChip® Human Mapping 50K Array: Enables copy number and allele specific analysis.
  

Additionally, Cogenics customers interested in comparative genomic hybridization studies for genome-wide surveying and profiling of genomic amplifications and deletions can access services based on the Agilent 2100 Bioanalyzer using the Agilent Human & Mouse Genome CGH Microarrays. Both human and mouse chips include 244,000 60-mer oligo probes that span the genome, with an average spatial resolution of ~35 kb, including coding and noncoding sequences.

Benefits of Cogenics whole genome analysis services include:

• Choice of Affymetrix GeneChip® Mapping Arrays
• Choice of Agilent Genome CGH Microarrays
• High throughput capacity
• Research or GLP-compliant services
• Custom Data Analysis

Samples
Clients submit purified genomic DNA, Buccal Swabs, or EDTA-preserved blood.

Results
Final Reports include raw microarray images, raw microarray data files, SNP scores and genotypes for each patient sample, as well as links to public and client databases where appropriate.