Individual SNP Genotyping
Analyses of small numbers (1-30) of SNPs are typically conducted in support of clinical trials. SNP profiling for clinical trial management purposes can be either prospective (using genotypic data to exclude/include patients in a clinical trial or to understand the metabolic profile of clinical trial patients) or retrospective (elucidating pharmacokinetic, pharmacodynamic, safety, tolerability, and efficiency outcomes through genotype/phenotype correlation analysis). To support these regulated SNP profiling applications, Cogenics offers GLP-compliant PCR/gel-based and other genotyping services for a number of drug metabolism enzymes and other clinically relevant genes:

• Choice of > 20 standard assays
• Availability of custom assays
• Rapid turnaround time of 3-5 days
• Research, GLP, or CLIA-compliant services

Samples
Clients submit purified genomic DNA, EDTA-preserved blood, buccal cells, or FTA® cards.

Results
Final Reports include SNP profiles for each patient sample.