Cogenics DMET Genotyping Service
Using the Affymetrix DMET panel, Cogenics provides a comprehensive assessment of metabolic and transporter genes, allowing you to use patient genotypes to predict drug response and metabolic profile.

Cogenics provides a full range of genomics services for both research and regulated projects, including a complete genotyping solution, from initial study design, sample collection, genotyping, through data analysis.   

Content
Developed in conjunction with Cogenics, Epidauros, and Eli Lilly, the Affymetrix DMET panel profiles 1,069 drug metabolism biomarkers

• Phase I Drug Metabolizing Enzymes (e.g. CYPs, ADHs, EPHs, …)
• Phase II Drug Metabolizing Enzymes (e.g. NATs, UGTs, SULTs, GSTs, …)
• Drug transport proteins (e.g. ABC transporters, drug uptake transporters, …)
• Receptors (e.g. ADRB2, CAR, hPXR, …)
• Includes rare markers with low minor allele frequency (MAF)
• Others

DMET is the only product available with comprehensive coverage of all ADME drug metabolism biomarkers, including common and rare variations, insertions, deletions, copy number, triallelic SNPs and pseudogenes.

Cogenics Benefits:

• Co-Developer of DMET
• First DMET Commercial Provider
• Experience processing thousands of DMET arrays
• GLP-compliant service
• Data generated in star nomenclature format
• Rapid turnaround time of 3-5 days

Recent Publications

• Caldwell, et al. CYP4F2 genetic variant alters required warfarin dose. Blood (2008).
• Deeken, et al. A pharmacogenetic study of docetaxel and thalidomide in patients with androgen-independent prostate cancer (AIPC) using targeted human DMET genotyping platform. Abstract #3580 ASCO Annual Meeting (2007).
• Daly, et al. Multiplex assay for comprehensive genotyping of genes involved in drug metabolism, excretion, and transport. Clinical Chemistry (2007).
• Dumauaul, et al. Comprehensive assessment of metabolic enzyme and transporter genes using the Affymetrix Targeted Genotyping System. Pharmacogenomics (2007).

Request additional information on our DMET Service