Individual SNP Genotyping
Analyses of small numbers (1-30) of SNPs are typically conducted in support of clinical trials. SNP profiling for clinical trial management purposes can be either prospective (using genotypic data to exclude/include patients in a clinical trial or to understand the metabolic profile of clinical trial patients) or retrospective (elucidating pharmacokinetic, pharmacodynamic, safety, tolerability, and efficiency outcomes through genotype/phenotype correlation analysis). To support these regulated SNP profiling applications, Cogenics offers GLP-compliant PCR/gel-based and other genotyping services for a number of drug metabolism enzymes and other clinically relevant genes:

• Choice of > 20 standard assays
• Availability of custom assays
• Rapid turnaround time of 3-5 days
• Research, GLP, or CLIA-compliant services

Samples
Clients submit purified genomic DNA, EDTA-preserved blood, buccal cells, or FTA® cards.

Results
Final Reports include SNP profiles for each patient sample.

Cogenics DMET Genotyping Service
Using the Affymetrix DMET array, Cogenics provides a comprehensive assessment of metabolic and transporter genes, allowing you to use patient genotypes to predict drug response and metabolic profile. 

• Phase I Drug Metabolizing Enzymes (e.g. CYPs, ADHs, EPHs, …)
• Phase II Drug Metabolizing Enzymes (e.g. NATs, UGTs, SULTs, GSTs, …)
• Drug transport proteins (e.g. ABC transporters, drug uptake transporters, …)
• Receptors (e.g. ADRB2, CAR, hPXR, …)
• Others

Cogenics offers:

• Ability to examine 1,068 SNPs associated with >160 drug metabolism and transport genes
• Experience processing thousands of DMET arrays
• GLP-compliant service
• Rapid turnaround time of 3-5 days

Request additional information on our DMET Service